Oxytocin

Oxytocin is a hormonal agent, a polypeptide analogue of the hormone of the posterior lobe of the pituitary gland. It has uterotonic, labor-stimulating and lactotropic action. Has a stimulating effect on the myometrium (especially at the end of pregnancy, during labor and directly during delivery).

Under the influence of oxytocin, the permeability of cell membranes for Ca2 + increases, the resting potential decreases and their excitability increases (a decrease in the membrane potential leads to an increase in the frequency, intensity and duration of contractions). Stimulates the secretion of breast milk, increasing the production of prolactin by the anterior pituitary gland. Shrinks the myoepithelial cells around the alveoli of the mammary gland, stimulates the flow of milk into the large ducts or sinuses, helping to increase the separation of milk. It is practically devoid of vasoconstrictor and antidiuretic action (only in high doses), does not cause contraction of the muscles of the bladder and intestines.

Oxytocin is used for females of agricultural and domestic animals: with weak labor, retention of the placenta, reflex agalactia, mastitis and uterine bleeding.


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